Alfa-fetoproteína y gamma-glutamiltranspeptidasa en pacientes con cirrosis hepática y carcinoma hepatocelular / Alpha-fetoprotein and gamma-glutamyltransferase in patients with liver cirrhosis and hepatocellular carcinoma
Rev. colomb. gastroenterol
; 25(1): 39-43, ene.-mar. 2010. tab
Article
in En, Es
| LILACS
| ID: lil-547727
Responsible library:
CO354
RESUMEN
Introducción:
El carcinoma hepatocelular (CHC) es una complicación de la cirrosis hepática (CH). El objetivo principal del estudio fue describir los niveles de los marcadores serológicos alfa-fetoproteína (AFP) y gamma-glutamiltranspeptidasa (GGT) en pacientes con CH y/o CHC.Métodos:
Estudio de corte transversal con 99 pacientes con diagnóstico de CH y/o CHC.Resultados:
Un total de 66 (66,7%) pacientes presentaban un diagnóstico de CH, 23 (23,2%) CHC asociado a CH y 10 (10,1%) CHC aislado. Los valores de AFP fueron mayores en individuos con CHC asociado a CH comparados con aquellos que solo tenían CH (20 y 2,93 ng/mL, p<0.05); los niveles de la GGT fueron también mayores en pacientes con CHC asociado a CH (208 y 109 UI/L, p<0,05). Ningún paciente con CHC tuvo en forma simultánea valores normales de AFP y GGT.Conclusiones:
En pacientes con CHC asociado a CH los niveles de AFP y GGT son significativamente más altos que individuos con CH aislada.ABSTRACT
Introduction:
Hepatocellular carcinoma (HCC) is one of the complications associated with liver cirrhosis (LC). The main objective of the present study was to describe the levels of the serological markers alpha-fetoprotein (AFP) and gamma-glutamyltranspeptidase (GGT) in patients with LC and/or HCC.Methods:
Cross sectional study that included 99 patients with a diagnosis of LC and/or HCC.Results:
66 (66.7%) patients had a diagnosis of LC, 23 (23.2%) had LC alongside with HCC and 10 (10.1%) had HCC without LC. AFP levels were higher in individuals with HCC associated with LC when compared with those with LC only (20 and 2.93 ng/mL, p <0.05), the levels of GGT were also higher in patients with HCC associated with LC (208 and 109 IU/L, p <0.05). Not a single patient with HCC had normal levels of AFP and GGT simultaneously.Conclusions:
In patients with HCC associated with LC levels of AFP and GGT were significantly higher than those found in individuals with LC only.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Alpha-Fetoproteins
/
Carcinoma, Hepatocellular
/
Liver Cirrhosis
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
Language:
En
/
Es
Journal:
Rev. colomb. gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2010
Document type:
Article
Affiliation country:
Colombia
Country of publication:
Colombia