Antiarrhythmic and cardioprotective effects of remifentanil in anesthetized dogs / Efectos antiarrítmicos y cardioprotectores de remifentanil en perros anestesiados
Arch. cardiol. Méx
; 79(3): 182-188, jul.-sept. 2009. ilus, graf
Article
in En
| LILACS
| ID: lil-565624
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To study the antiarrhythmic effect of remifentanil in experimental arrhythmias in dogs.METHODS:
We used dogs weighing 12 kg-18 kg anesthetized with 30 mg/kg sodium pentobarbital given intravenously. Ventricular arrhythmia, ventricular fibrillation and death were induced with digoxin (9 microg/kg/min). In another model, two types of arrhythmia were induced in the right atrium, one of them with aconitine crystals placed on the right atrium and the other was induced in the basement of the right atrium by electrical stimulation. The potential antiarrhythmic action of remifentaniL was investigated in ventricular and atrial arrhythmias by the administration of an intravenous bolus after toxic signs were evident. Thus, two arrhythmias with different mechanisms were generated. Leads DII, unipolar left intraventricular and right atrial leads, and left ventricular pressure were used to record control tracings and tracings in presence of remifentanil, during ventricular arrhythmia.RESULTS:
Remifentanil abolished toxic effects of digoxin, it eliminated the A-V dissociation and ventricular extrasystoles, reverting to sinus rhythm in each case. Remifentanil extended the time to reach lethal doses from 63.25 +/- 11.3 to 100 +/- 11.8 min. These effects were blocked by naloxone (0.01 microg/kg) applied before remifentanil. In the two arrhythmias model, remifentanil suppressed both, ectopic focus and atrial flutter.CONCLUSIONS:
Remifentanil elicits antiarrhythmic and cardioprotective effects in experimental ventricular arrhythmias induced by digoxin and in a model of two atrial arrhythmias induced by aconitine and by electrical stimulation.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Piperidines
/
Arrhythmias, Cardiac
/
Heart Diseases
/
Analgesics, Opioid
Limits:
Animals
Language:
En
Journal:
Arch. cardiol. Méx
Journal subject:
CARDIOLOGIA
Year:
2009
Document type:
Article
Affiliation country:
Mexico
Country of publication:
Mexico