The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
Clinics
; 66(5): 743-746, 2011. tab
Article
in En
| LILACS
| ID: lil-593834
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.METHOD:
The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.RESULT:
The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).CONCLUSION:
The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Superoxide Dismutase
/
Lipid Peroxidation
/
Oxidative Stress
/
Choroidal Neovascularization
/
Glutathione Peroxidase
/
Macular Degeneration
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2011
Document type:
Article
Affiliation country:
Turkey