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Determination of beta S haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
Cabral, Cynthia Hatsue Kitayama; Serafim, Édvis Santos Soares; Medeiros, Waleska Rayane Dantas Bezerra de; Fernandes, Thales Allyrio Araújo de Medeiros; Kimura, Elza Miyuki; Costa, Fernando Ferreira; Sonati, Maria de Fátima; Rebecchi, Ivanise Marina Moretti; Medeiros, Tereza Maria Dantas de.
Affiliation
  • Cabral, Cynthia Hatsue Kitayama; Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas e Toxicológicas. Natal. BR
  • Serafim, Édvis Santos Soares; Hemocentro Dalton Barbosa Cunha. Natal. BR
  • Medeiros, Waleska Rayane Dantas Bezerra de; Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas e Toxicológicas. Natal. BR
  • Fernandes, Thales Allyrio Araújo de Medeiros; Universidade do Estado do Rio Grande do Norte. Departamento de Ciências Biomédicas. Mossoró. BR
  • Kimura, Elza Miyuki; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Patologia Clínica. Campinas. BR
  • Costa, Fernando Ferreira; Universidade Estadual de Campinas. Hemocentro. Campinas. BR
  • Sonati, Maria de Fátima; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Patologia Clínica. Campinas. BR
  • Rebecchi, Ivanise Marina Moretti; Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas e Toxicológicas. Natal. BR
  • Medeiros, Tereza Maria Dantas de; Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas e Toxicológicas. Natal. BR
Genet. mol. biol ; 34(3): 421-424, 2011. tab
Article in En | LILACS | ID: lil-595989
Responsible library: BR1.1
ABSTRACT
βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5 percent) were identified with genotype CAR/CAR, 9 (19.1 percent) CAR/BEN, 6 (12.8 percent) CAR/CAM, 1 (2.1 percent) BEN/BEN, 2 (4.3 percent) CAR/Atp, 1 (2.1 percent) BEN/Atp and 1 (2.1 percent) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Haplotypes / Beta-Globins / Anemia, Sickle Cell Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 2011 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Haplotypes / Beta-Globins / Anemia, Sickle Cell Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 2011 Document type: Article Affiliation country: Brazil