Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)
Rev. bras. farmacogn
; 22(1): 137-143, Jan.-Feb. 2012. graf, tab
Article
in En
| LILACS
| ID: lil-607586
Responsible library:
BR1.1
ABSTRACT
Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Language:
En
Journal:
Rev. bras. farmacogn
Journal subject:
FARMACIA
Year:
2012
Document type:
Article
Affiliation country:
Brazil