The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
; 106(8): 1055-1057, Dec. 2011. ilus, graf, tab
Article
in En
| LILACS
| ID: lil-610987
Responsible library:
BR1.1
ABSTRACT
In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-Iβ-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain increased the trypanocidal activity while maintaining its cytotoxicity. The selective index shows that MTZ-I was 10 times more active against T. cruzi than it was against mammalian cells. The modification of MTZ side chains provides a promising avenue for the development of new drugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Trypanocidal Agents
/
Trypanosoma cruzi
/
Beta-Cyclodextrins
/
Metronidazole
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Brazil