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Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni
Grenfell, Rafaella Fortini Queiroz; Martins, Watson; Drummond, Sandra Costa; Antunes, Carlos Maurício de Figueiredo; Voieta, Izabela; Otoni, Alba; Oliveira, Áureo Almeida de; Silva-Moraes, Vanessa; Oliveira, Eduardo Ribeiro de; Oliveira, Edward; Lambertucci, José Roberto; Fonseca, Cristina Toscano; Coelho, Paulo Marcos Zech.
Affiliation
  • Grenfell, Rafaella Fortini Queiroz; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Martins, Watson; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Drummond, Sandra Costa; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Antunes, Carlos Maurício de Figueiredo; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Voieta, Izabela; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Otoni, Alba; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Oliveira, Áureo Almeida de; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Silva-Moraes, Vanessa; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Oliveira, Eduardo Ribeiro de; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Oliveira, Edward; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Lambertucci, José Roberto; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Fonseca, Cristina Toscano; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
  • Coelho, Paulo Marcos Zech; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte. BR
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;46(2): 208-213, Mar-Apr/2013. tab, graf
Article in En | LILACS | ID: lil-674665
Responsible library: BR1.1
ABSTRACT
Introduction The diagnosis of schistosomiasis mansoni on early stages of infection is important to prevent late morbidity. A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection based on the detection of specific IgG for schistosomula tegument antigens (ELISA-SmTeg) was developed by our group. Methods We describe here an acute outbreak involving a travel group of 80 individuals from a non-endemic area of the State of Minas Gerais, Brazil. These individuals were in contact with a freshwater pool where Biomphalaria glabrata was found. Results obtained from our new methodology were compared to IgG antibody titers against soluble worm antigenic preparation (SWAP) by ELISA and, also to parasitological examination, nuclear magnetic resonance and clinical findings. Results ELISA-SmTeg was capable of detecting 64 positive cases among the 80 individuals participating at the survey with a positivity ratio of 80% and a higher sensitivity than ELISA-SWAP that was only sensitive for 56% of positive cases. Besides, a significant correlation was found for the severity of the infection and the specific IgG titers against SmTeg. Conclusions Our data showed that ELISA-SmTeg might serve as the initial diagnostic tool for acute stages of the infection in community-based helminth control programs or for the surveillance of individuals from non-endemic areas. .
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Schistosoma mansoni / Travel / Schistosomiasis mansoni / Immunoglobulin G / Antibodies, Helminth / Disease Outbreaks / Antigens, Helminth Type of study: Diagnostic_studies Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2013 Document type: Article Affiliation country: Brazil Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Schistosoma mansoni / Travel / Schistosomiasis mansoni / Immunoglobulin G / Antibodies, Helminth / Disease Outbreaks / Antigens, Helminth Type of study: Diagnostic_studies Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2013 Document type: Article Affiliation country: Brazil Country of publication: Brazil