Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos / In vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment: Report of two cases
Rev. méd. Chile
; 141(5): 669-673, mayo 2013. ilus
Article
in Es
| LILACS
| ID: lil-684376
Responsible library:
CL1.1
ABSTRACT
Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical chemotherapy response. Cancer cells isolated from peritoneal fluid with suspected ovarian cancer were tested for cytotoxicity with corresponding chemotherapy regimens. Circulating Cal25 levels and attending physician consultation determined clinical course and response to chemotherapy. The in vitro assay result correlated with Cal25 levels, progression free survival and attending physician evaluation. The assay predicted correctly the failure of two successive chemotherapy regimes in the first patient, while predicting a favorable clinical response in the second subject.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Ovarian Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2013
Document type:
Article
/
Project document
Affiliation country:
Chile