Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 36(1): 39-46, Jan-Mar. 2014. graf
Article
in English
| LILACS
| ID: lil-702639
Responsible library:
BR1.1
ABSTRACT
Objective: In the present study, we aimed to examine the effects of repeated D-amphetamine (AMPH) exposure, a well-accepted animal model of acute mania in bipolar disorder (BD), and histone deacetylase (HDAC) inhibitors on locomotor behavior and HDAC activity in the prefrontal cortex (PFC) and peripheral blood mononuclear cells (PBMCs) of rats. Moreover, we aimed to assess brain-derived neurotrophic factor (BDNF) protein and mRNA levels in these samples. Methods: We treated adult male Wistar rats with 2 mg/kg AMPH or saline intraperitoneally for 14 days. Between the 8th and 14th days, rats also received 47.5 mg/kg lithium (Li), 200 mg/kg sodium valproate (VPT), 2 mg/kg sodium butyrate (SB), or saline. We evaluated locomotor activity in the open-field task and assessed HDAC activity in the PFC and PBMCs, and BDNF levels in the PFC and plasma. Results: AMPH significantly increased locomotor activity, which was reversed by all drugs. This hyperactivity was associated with increased HDAC activity in the PFC, which was partially reversed by Li, VPT, and SB. No differences were found in BDNF levels. Conclusion: Repeated AMPH administration increases HDAC activity in the PFC without altering BDNF levels. The partial reversal of HDAC increase by Li, VPT, and SB may account for their ability to reverse AMPH-induced hyperactivity. .
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Prefrontal Cortex
/
Dopamine Uptake Inhibitors
/
Brain-Derived Neurotrophic Factor
/
Dextroamphetamine
/
Histone Deacetylases
/
Motor Activity
Type of study:
Evaluation study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio Grande do Sul (UFRGS)/BR