Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats
Acta cir. bras
; Acta cir. bras;29(6): 371-375, 06/2014. tab, graf
Article
in En
| LILACS
| ID: lil-711590
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the antioxidant and antiperoxidative effects of oil mixes of high ratio Omega-9Omega-6 and low ratio Omega-6Omega-3 in the third day after tooth extraction in rats.METHODS:
Thirty-two male Wistar rats (270-310g) were randomly distributed in two groups Control (n=24) and Test (n=8). Control group was divided into three subgroups (n=8) G1 Sham-Saline; G2 Saline; G3 Isolipid. G1 and G2 animals received NaCl 0.9% while G3 rats were treated with an isolipid mixture (alpha-linolenic acid - ALA) containing -6/-3 oils (81 ratio) and-9/-6 (0.41 ratio). Test group animals (G4) received oily mixtures (alpha-linolenic acid - ALA, docosahexaenoic acid - DHA, eicosapentaenoic acid - EPA) of -6/-3 (1.41 ratio) and -9/-6 (3.41 ratio). Saline and oils were administered by gavage during four days before and three days after first mandibular molar extraction. Following, samples (arterial blood and alveolar mucosa) were collected for glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) assays.RESULTS:
Oil mixes induced a significant decrease in GSH and TBARS tissue and plasma concentrations in the third day post-surgery.CONCLUSION:
Gavage administration of oil mixes of high ratio Omega-9Omega-6 and low ratio Omega-6Omega-3 after molar extraction in rats induces a significant decrease in lipid peroxidation. .Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Tooth Extraction
/
Lipid Peroxidation
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Oxidative Stress
/
Fatty Acids
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Acta Cir Bras
/
Acta cir. bras
/
Acta cir. bras. (Online)
/
Acta cirúrgica brasileira (Impresso)
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil