Cáncer de mama metastásico: Caracterización de una cohorte según subtipos / Survival of patients with metastatic breast cancer according to pathological types of tumors
Rev. méd. Chile
; 142(4): 428-435, abr. 2014. graf, tab
Article
in Es
| LILACS
| ID: lil-716214
Responsible library:
CL1.1
ABSTRACT
Background:
The prognosis of breast cancer (BC) is in part determined by the stage at diagnosis and its pathological characteristics.Aim:
To evaluate the association between survival of women with metastatic breast cancer and pathological features of the tumor. Patients andMethods:
We obtained clinical and pathological data from patients diagnosed with a metastatic BC between 1999 and 2013. The expression of estrogen (ER) and progesterone (PR) receptors and human epidermal growth factor receptor 2 (HER2) was determined by immunohistochemistry. Clinicopathological subtypes were defined as Luminal A ER or PR positive, HER2 negative, histological grade (HG) 1 or 2; Luminal B ER or PR positive, HER2 negative or positive or HG 3; triple negative (TN) ER, PR and HER2 negative, independent of the HG, positive HER2 ER, PR negative and HER2 positive, independent of HG. We analyzed survival based on these subtypes.Results:
We identified 54 patients aged 24 to 85 years, with metastatic BC at diagnosis. Seventy five percent had luminal tumors; 19.6% HER2 positive and 7.8% were TN. In 61% of evaluable tumors, HG was classified as 3. The frequency of HER2 positive and high HG tumors was greater in these patients with metastatic BC than in a non-metastatic local BC cohort. Survival was higher among patients with Luminal tumors than in women with non-Luminal cancer (56.4 and 11.4 months, respectively, p = 0.04).Conclusions:
Patients with metastatic BC at diagnosis often had HER2 positive tumors and high HG. As in other studies, ER positive tumors had a better survival.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Breast Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2014
Document type:
Article
Affiliation country:
Chile
Country of publication:
Chile