Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
Clinics
; Clinics;69(9): 621-626, 9/2014. graf
Article
in En
| LILACS
| ID: lil-725409
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules.METHOD:
The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry.RESULTS:
Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin.CONCLUSIONS:
These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus. .Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Status Epilepticus
/
Indomethacin
/
Monokines
/
Cyclooxygenase Inhibitors
/
Receptors, Bradykinin
/
Hippocampus
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil