Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment
Rev. bras. hematol. hemoter
; 36(5): 345-350, Sep-Oct/2014. tab, graf
Article
in En
| LILACS
| ID: lil-725681
Responsible library:
BR408.1
ABSTRACT
Objective:
To evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment.Methods:
Data were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and KruskalWallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test.Results:
There was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy.Conclusions:
There are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature...Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Splenomegaly
/
Enzyme Replacement Therapy
/
Gaucher Disease
/
Anemia
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Rev. bras. hematol. hemoter
Journal subject:
HEMATOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil