Activity and safety of sunitinib in poor risk metastatic renal cell carcinoma patients
Int. braz. j. urol
; 40(6): 835-841, Nov-Dec/2014. tab, graf
Article
in En
| LILACS
| ID: lil-735985
Responsible library:
BR1.1
ABSTRACT
Purpose To assess the activity, safety and treatment patterns of sunitinib in patients with poor-risk metastatic renal cell carcinoma (mRCC). Materials and Methods We retrospectively reviewed the charts of poor risk patients treated with sunitinib from October 2006 to July 2013 who met the eligibility criteria. The primary endpoint was overall survival (OS). Tumor radiological response was measured according to RECIST 1.1 and adverse events (AEs) were assessed through standard criteria. Results Median OS was 8.16 months (95% CI, 5.73-10.59). Of the 53 patients included in this analysis, 9 (17.0%) achieved partial response, 12 (22.6%) had stable disease. Median treatment duration was 3.30 months (95% CI 1.96-4.63) and 26.4% of patients discontinued treatment due to toxicity. Grade 3 or higher AEs occurred in 39.6% of patients, the most common being fatigue (15.1%), neutropenia (9.5%), nausea, vomiting and diarrhea (7.5% each). Discussion Sunitinib may benefit some unselected poor-risk patients, although the rates of AEs and drug discontinuation suggest a need for careful patient monitoring. .
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Pyrroles
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Carcinoma, Renal Cell
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Indoles
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Kidney Neoplasms
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Antineoplastic Agents
Type of study:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Brazil