Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin
Braz. j. microbiol
; 45(4): 1341-1347, Oct.-Dec. 2014. graf, tab
Article
in En
| LILACS
| ID: lil-741285
Responsible library:
BR1.1
ABSTRACT
Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with a commercial antibiotic streptomycin. Phytol was a compound identified in all extracts by GC/MS, being majoritary component in Plectranthus barbatus and Rosmarinus officinalis. The Gram-positive bacteria were more sensitive to ethanol extracts, and Plectranthus barbatus and Rosmarinus officinalis were the most active extracts. Ethanol extracts exhibited a synergetic effect with streptomycin. These results encourage additional studies, in order to evaluate the possibilities of using ethanol extracts of Lamiaceae family as natural source for antibacterial activity.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Bacteria
/
Plant Extracts
/
Streptomycin
/
Lamiaceae
/
Drug Synergism
/
Volatile Organic Compounds
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Braz. j. microbiol
Journal subject:
MICROBIOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil