Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile / Human papillomavirus testing in cervical cancer screening at a public health service of Santiago, Chile
Rev. méd. Chile
; 143(1): 56-62, ene. 2015. ilus, tab
Article
in Es
| LILACS
| ID: lil-742551
Responsible library:
CL1.1
ABSTRACT
Background:
Molecular techniques for human papillomavirus (HPV) detection have a good performance as screening tests and could be included in cervical cancer early detection programs. We conducted a population-based trial comparing HPV detection and Papanicolaou as primary screening tests, in a public health service in Santiago, Chile.Aim:
To describe the experience of implementing this new molecular test and present the main results of the study. Material andMethods:
Women aged 25 to 64 enrolled in three public health centers were invited to participate. In all women, samples were collected for Papanicolaou and HPV DNA testing, and naked-eye visual inspection of the cervix with acetic acid was performed. Women with any positive screening test were referred to the local area hospital for diagnostic confirmation with colposcopy and biopsy of suspicious lesions.Results:
Screening results were obtained for 8265 women, of whom 931 (11.3%) were positive to any test. The prevalence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was 1.1%; nine women had invasive cervical cancer. Sensitivities for the detection of CIN2+ were 22.1% (95% confidence interval (CI) 16.4-29.2) for Papanicolaou and 92.7% (95% CI 84.4-96.8) for HPV testing; specificities were 98.9% (95% CI 98.7-99.0) and 92.0% (95% CI 91.4-92.6) respectively.Conclusion:
This experience showed that the implementation of a molecular test for cervical cancer screening is not a major challenge in Chile it was well accepted by both the health team and the participants, and it may improve the effectiveness of the screening program.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Socioeconomic Factors
/
Physical Fitness
/
Employment
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Aspects:
Determinantes_sociais_saude
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Chile
/
Europa
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2015
Document type:
Article
/
Project document
Affiliation country:
Chile
Country of publication:
Chile