Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo
An. bras. dermatol
; 91(1): 23-26, Jan.-Feb. 2016. tab
Article
in En
| LILACS
| ID: lil-776422
Responsible library:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4.OBJECTIVES:
To examine the association of serum IgE levels and the clinical severity of injuries.METHODS:
This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Cases were classified by lesion severity as mild, moderate, and severe. Descriptive statistics were analyzed, and chi-square test was performed.RESULTS:
We included 21 actinic prurigo patients and 21 subjects without disease; 11 patients with actinic prurigo had elevated serum IgE levels, and 10 had low serum levels. Six actinic prurigo (AP) patients with elevated serum levels of IgE had moderate injuries, 4 had severe injuries, and 1 had minor injuries. Eight out of 10 patients with normal IgE levels presented with minor injuries in the clinical evaluation. The 21 controls did not have increased serum IgE levels.CONCLUSIONS:
Elevated IgE levels are associated with moderate to severe clinical lesions, suggesting that actinic prurigo entails a type IV subtype b hypersensitivity response in which Th2 cells predominate.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Photosensitivity Disorders
/
Skin Diseases, Genetic
/
Immunoglobulin E
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Mexico
Country of publication:
Brazil