Psoriasis: new comorbidities
An. bras. dermatol
; An. bras. dermatol;91(1): 8-14, Jan.-Feb. 2016. graf
Article
in En
| LILACS
| ID: lil-776435
Responsible library:
BR1.1
ABSTRACT
Abstract Psoriasis is a chronic inflammatory disease associated with several comorbidities. A few decades ago, it was considered an exclusive skin disease but today it is considered a multisystem disease. It is believed that 73% of psoriasis patients have at least one comorbidity. Studies have demonstrated the association of psoriasis with inflammatory bowel disease, uveitis, psychiatric disorders, metabolic syndrome and its components and cardiovascular diseases. The systemic inflammatory state seems to be the common denominator for all these comorbidities. This work aims at presenting a review of the current literature on some new comorbidities that are associated with psoriasis as osteoporosis, obstructive sleep apnea and chronic obstructive pulmonary disease. While there is still controversy, many studies already point to a possible bone involvement in patients with psoriasis, especially in the male group, generally less affected by osteoporosis. Psoriasis and chronic obstructive pulmonary disease present some risk factors in common as obesity, smoking and physical inactivity. Besides, both diseases are associated with the metabolic syndrome. These factors could be potential confounders in the association of the two diseases. Further prospective studies with control of those potential confounders should be developed in an attempt to establish causality. Existing data in the literature suggest that there is an association between obstructive sleep apnea and psoriasis, but studies performed until now have involved few patients and had a short follow-up period. It is, therefore, premature to assert that there is indeed a correlation between these two diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Osteoporosis
/
Psoriasis
/
Bone Diseases, Metabolic
/
Sleep Apnea, Obstructive
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
ABD: Anais brasileiros de dermatologia
/
An Bras Dermatol
/
An. bras. dermatol
/
An. bras. dermatol. (Online)
/
Anais brasileiros de dermatologia (Impresso)
Journal subject:
DERMATOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil