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Pituitary-testicular axis in benznidazole-treated rata
Favaretto, A. L. V; Rodrigues, J. Antunes; Vieira, C. L. L. F. R; Carvalho, T. L. Lamano.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;23(8): 719-22, 1990. tab
Article in En | LILACS | ID: lil-92329
Responsible library: BR26.1
RESUMO
Benznidazole is used extensively throughout Latin America as an antiparasitic chemotherapeutic agent against chagasica infection. We have shown that rats chronically treated with 80 mg benznidazole Kg-1 day-1 for 30, days present severe testicular atrophy and arrest of spermatognesis. In the present experiments, plasma levels of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (Prl- were inbestigated in rats receiving 10, 40 and 80 mg benznidazole Kg-1 day-1 for 30 days. No significant change in T, LH or Prl levels was observed in treated rats (P > 0.05). Plasma FSH concentration, however, was markedly invreased (P < 0.05 by benzidazole treatment (40 and 80 mgKg-1 day-1) and remained high for 90 days after drug treatment was discontinued
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Collection: 01-internacional Database: LILACS Main subject: Prolactin / Testosterone / Benzimidazoles / Luteinizing Hormone / Follicle Stimulating Hormone / Antiprotozoal Agents Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1990 Document type: Article / Congress and conference Country of publication: Brazil
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Collection: 01-internacional Database: LILACS Main subject: Prolactin / Testosterone / Benzimidazoles / Luteinizing Hormone / Follicle Stimulating Hormone / Antiprotozoal Agents Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1990 Document type: Article / Congress and conference Country of publication: Brazil