Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.

Chan, W N; Evans, J M; Hadley, M S; Herdon, H J; Jerman, J C; Parsons, A A; Read, S J; Stean, T O; Thompson, M; Upton, N

Chan, W N; Evans, J M; Hadley, M S; Herdon, H J; Jerman, J C; Parsons, A A; Read, S J; Stean, T O; Thompson, M; Upton, N.

Affiliation

Chan WN; SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.

Bioorg Med Chem Lett ; 9(2): 285-90, 1999 Jan 18.

Article in En | MEDLINE | ID: mdl-10021946

ABSTRACT

ABSTRACT

Optimisation of novel cis- and trans-4-(substituted-amido)benzopyran-3-ol derivatives has led to the identification of SB-220453 20 with an in vivo pre-clinical CNS profile predictive of potential antimigraine activity.

Subject(s)

Benzamides/pharmacology; Benzopyrans/pharmacology; Migraine Disorders/drug therapy; Animals; Benzamides/chemistry; Dose-Response Relationship, Drug; Methylcellulose/pharmacology; Mice; Rats; Seizures/chemically induced; Seizures/drug therapy; Sumatriptan/pharmacology; Temperature; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Benzopyrans / Migraine Disorders Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 1999 Document type: Article Affiliation country: United kingdom

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