L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients.
Oncol Rep
; 6(2): 441-4, 1999.
Article
in En
| MEDLINE
| ID: mdl-10023018
ABSTRACT
L-myc genotypes have been correlated with prognosis in different human tumors. Its role in colorectal carcinoma (CRC) is still unclear. This study aimed to assess the L-myc genotypes in 99 Hong Kong Chinese CRC patients by PCR-RFLP techniques. The results obtained were correlated with clinical, histological and pathological parameters and genetic alterations. The observed frequency of L-myc genotypes (LLLSSS) was 274626. The ratio of S to L alleles was 0.510.49. Distribution of L-myc genotypes and alleles in Hong Kong Chinese CRC was similar to that of healthy Chinese and CRC patients of other ethnic origins. The homozygous SS genotype was significantly associated with Dukes' stages C versus B. Other parameters including sex, differentiation status and survival, and genetic alterations such as p53 and Ki-ras mutations and Dcc LOH had no significant association with L-myc SS genotype.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectal Neoplasms
/
Polymorphism, Restriction Fragment Length
/
Colorectal Neoplasms
/
Genes, myc
/
Proto-Oncogene Proteins c-myc
/
Colonic Neoplasms
/
Asian People
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Oncol Rep
Journal subject:
NEOPLASIAS
Year:
1999
Document type:
Article
Affiliation country:
China