Antibiotic-induced endotoxemia in a patient with endogenous endophthalmitis.
Acta Ophthalmol Scand
; 77(1): 110-3, 1999 Feb.
Article
in En
| MEDLINE
| ID: mdl-10071162
ABSTRACT
PURPOSE:
The aim of the study is to describe a case of suspected endotoxin-induced uveitis associated with septic endogenous endophthalmitis followed by antibiotic-induced endotoxemia.METHODS:
The human leukocyte antigen (HLA) typing of peripheral leukocytes was studied by lymphocytotoxicity technique. Histological and immunohistochemical studies of paraffin embedded specimen were conducted.RESULTS:
Findings of HLA typing revealed positive reaction for B 51, Cw 3, DR 8, DR 11, DQ 3. The vitreous body of an eviscerated eye was occupied by the non-specific granulomatous tissue, composed of fibroblast, plasma cells, and Sudan black staining positive foamy cells, including melaniferous phagocytes, identified as CD 68 positive macrophage.CONCLUSION:
It is suggested that antibiotic-induced endotoxemia of a patient with septic endogenous endophthalmitis produced endotoxin-induced uveitis under an upregulation of HLA and endotoxin activated macrophages may release cytokines, followed by fibrin formation and subsequent granuloma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Klebsiella Infections
/
Eye Infections, Bacterial
/
Endophthalmitis
/
Endotoxemia
/
Drug Therapy, Combination
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Acta Ophthalmol Scand
Journal subject:
OFTALMOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
Japan