Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section.
Am J Obstet Gynecol
; 180(3 Pt 1): 670-6, 1999 Mar.
Article
in En
| MEDLINE
| ID: mdl-10076146
ABSTRACT
OBJECTIVE:
The goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of uterine atony after cesarean section. STUDYDESIGN:
We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 microg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for uterine atony. A variable sample size, sequential design was used.RESULTS:
The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P <.05.CONCLUSIONS:
Carbetocin, a new drug for the prevention of uterine atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxytocics
/
Uterine Contraction
/
Oxytocin
/
Cesarean Section
/
Postpartum Hemorrhage
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
America do norte
Language:
En
Journal:
Am J Obstet Gynecol
Year:
1999
Document type:
Article