The ability of polyethylene glycol conjugated bovine hemoglobin (PEG-Hb) to adequately deliver oxygen in both exchange transfusion and top-loaded rat models.

Conover, C D; Linberg, R; Shum, K L; Shorr, R G

Conover, C D; Linberg, R; Shum, K L; Shorr, R G.

Affiliation

Conover CD; Research and Development, Formulations-Toxicology Department, Enzon Inc., Piscataway, NJ 08854, USA.

Artif Cells Blood Substit Immobil Biotechnol ; 27(2): 93-107, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10092932

Subject(s)

Blood Substitutes/metabolism; Hemoglobins/metabolism; Oxygen/metabolism; Polyethylene Glycols/metabolism; Animals; Blood Pressure; Blood Substitutes/administration & dosage; Blood Substitutes/pharmacokinetics; Cattle; Female; Heart Rate; Hemoglobins/administration & dosage; Hemoglobins/pharmacokinetics; Injections, Intravenous; Kidney/metabolism; Polyethylene Glycols/administration & dosage; Polyethylene Glycols/pharmacokinetics; Rats; Rats, Sprague-Dawley; Spleen/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Polyethylene Glycols / Blood Substitutes / Hemoglobins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Artif Cells Blood Substit Immobil Biotechnol Journal subject: BIOTECNOLOGIA / TRANSPLANTE Year: 1999 Document type: Article Affiliation country: United States Country of publication: United kingdom

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