Ultrastructural interactions in the microvasculature of human endometrial adenocarcinoma.
Gynecol Oncol
; 73(1): 76-86, 1999 Apr.
Article
in En
| MEDLINE
| ID: mdl-10094884
ABSTRACT
OBJECTIVES:
Our purpose was to study the ultrastructural morphology of the microvasculature of human endometrial adenocarcinoma and to determine the effect of this malignancy on cell-to-cell communication between the components of the microvasculature and with the other tissue compartments of human endometrium. Methods. Multiple cases of human endometrial adenocarcinoma were studied and graded by light microscopy. Six cases of Grade I and six cases of Grade II were selected. Two blocks per case were studied ultrastructurally.RESULTS:
In contrast to our expectation that the ultrastructure of tumor vessels would suggest a great deal of proliferation and new vessel formation, we found that tumor vessels displayed a high degree of cellular differentiation, in the form of numerous and varied cell-to-cell contacts, and large amounts of protein production.CONCLUSIONS:
The morphology of the microvasculature of endometrial adenocarcinoma suggests an active rather than passive role in tumor vessels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenocarcinoma
/
Endometrial Neoplasms
Limits:
Female
/
Humans
Language:
En
Journal:
Gynecol Oncol
Year:
1999
Document type:
Article
Affiliation country:
United States