A novel, orally administered nucleoside analogue, OGT 719, inhibits the liver invasive growth of a human colorectal tumor, C170HM2.

Rohlff, C; Watson, S A; Morris, T M; Skelton, L; Jackman, A L; Page, M J

Rohlff, C; Watson, S A; Morris, T M; Skelton, L; Jackman, A L; Page, M J.

Affiliation

Rohlff C; Oxford GlycoSciences, Abingdon, United Kingdom. Christian.Rohlff@ogs.co.uk

Cancer Res ; 59(6): 1268-72, 1999 Mar 15.

Article in En | MEDLINE | ID: mdl-10096558

Subject(s)

Antineoplastic Agents/therapeutic use; Colorectal Neoplasms/drug therapy; Liver Neoplasms/secondary; Administration, Oral; Animals; Asialoglycoprotein Receptor; Cell Membrane/drug effects; Cell Membrane/metabolism; Colorectal Neoplasms/pathology; Fluorouracil/therapeutic use; Humans; Liver Neoplasms/prevention & control; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Receptors, Cell Surface/metabolism; Thymidylate Synthase/antagonists & inhibitors; Thymidylate Synthase/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Liver Neoplasms / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Cancer Res Year: 1999 Document type: Article Affiliation country: United kingdom Country of publication: United States

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