ICAM-3 and E-selectin endothelial cell expression differentiate two phases of angiogenesis in infantile hemangiomas.
J Cutan Pathol
; 26(1): 17-24, 1999 Jan.
Article
in En
| MEDLINE
| ID: mdl-10189240
ABSTRACT
Cellular adhesion molecules are newly identified mediators of angiogenesis. Infantile hemangiomas, characterized in the early stages by a proliferation of poorly differentiated vessels followed in the late stages by a vascular differentiation and regression of the tumor, represent an interesting model to study angiogenesis. We studied by immunohistochemistry the distribution of HLA-DR and three adhesion molecules ICAM-3, E-selectin and VCAM-1 on endothelial cells in different stages of vessel differentiation in infantile hemangiomas. We found high levels of ICAM-3 expression on proliferating vessels, while its expression was low or undetectable on well differentiated vessels. A different set of E-selectin antibodies showed a more heterogenous pattern of distribution and VCAM-1 antigens were found in both proliferating and differentiated vessels. HLA-DR expression on endothelial cells was inversely correlated to the vascular differentiation. Our results are consistent with the hypothesis that ICAM-3 plays a role in the early stages of vessel formation. Our results also suggest that variation of E-selectin and HLA-DR expression may be related either to vessel differentiation or may reflect the acquisition of an activated endothelial cell status.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Endothelium, Vascular
/
Antigens, Differentiation
/
Antigens, CD
/
Cell Adhesion Molecules
/
Hemangioma, Capillary
/
E-Selectin
/
Neovascularization, Pathologic
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
J Cutan Pathol
Year:
1999
Document type:
Article
Affiliation country:
France