Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

Sánchez, I; Xu, C J; Juo, P; Kakizaka, A; Blenis, J; Yuan, J

Sánchez, I; Xu, C J; Juo, P; Kakizaka, A; Blenis, J; Yuan, J.

Affiliation

Sánchez I; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Neuron ; 22(3): 623-33, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10197541

Subject(s)

Adaptor Proteins, Signal Transducing; Apoptosis/physiology; Caspases/physiology; Neurons/physiology; Peptides/physiology; Viral Proteins; Animals; Carrier Proteins/biosynthesis; Carrier Proteins/metabolism; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases/genetics; Cell Line; Cysteine Proteinase Inhibitors/biosynthesis; Cysteine Proteinase Inhibitors/metabolism; Enzyme Activation; Fas-Associated Death Domain Protein; Fluorescent Antibody Technique, Direct; Humans; Immunoblotting; Microscopy, Confocal; Mutation; Neurons/enzymology; Plasmids; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Repetitive Sequences, Amino Acid; Serpins/biosynthesis; Serpins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Viral Proteins / Apoptosis / Caspases / Adaptor Proteins, Signal Transducing / Neurons Limits: Animals / Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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