Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.
Bioorg Med Chem Lett
; 9(5): 749-54, 1999 Mar 08.
Article
in En
| MEDLINE
| ID: mdl-10201841
ABSTRACT
Human beta3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over beta1 and beta2 binding. L-760,087 (4a) and L-764,646 (5a) (beta3 EC50 = 18 and 14 nM, respectively) stimulate lipolysis in rhesus monkeys (ED50 = 0.2 and 0.1 mg/kg, respectively) with minimal effects on heart rate. Oral absorption in dogs is improved over other urea analogs.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Adrenergic, beta
/
Adrenergic beta-Agonists
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
1999
Document type:
Article
Affiliation country:
United States