Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation.

Kitchens, M E; Forsthoefel, A M; Rafique, Z; Spencer, H T; Berger, F G

Kitchens, M E; Forsthoefel, A M; Rafique, Z; Spencer, H T; Berger, F G.

Affiliation

Kitchens ME; Department of Biological Sciences, University of South Carolina.

J Biol Chem ; 274(18): 12544-7, 1999 Apr 30.

Article in En | MEDLINE | ID: mdl-10212232

Subject(s)

Gene Expression Regulation, Enzymologic; Protein Biosynthesis; Thymidylate Synthase/biosynthesis; Base Sequence; DNA Primers; Enzyme Stability/drug effects; Floxuridine/pharmacology; Humans; Ligands; Mutagenesis, Site-Directed; Protein Binding; RNA, Messenger/genetics; Thymidylate Synthase/genetics; Thymidylate Synthase/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Protein Biosynthesis / Gene Expression Regulation, Enzymologic Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 1999 Document type: Article Country of publication: United States

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