Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.

Cappelli, A; Anzini, M; Vomero, S; Canullo, L; Mennuni, L; Makovec, F; Doucet, E; Hamon, M; Menziani, M C; De Benedetti, P G; Bruni, G; Romeo, M R; Giorgi, G; Donati, A

Cappelli, A; Anzini, M; Vomero, S; Canullo, L; Mennuni, L; Makovec, F; Doucet, E; Hamon, M; Menziani, M C; De Benedetti, P G; Bruni, G; Romeo, M R; Giorgi, G; Donati, A.

Affiliation

Cappelli A; Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Via Banchi di Sotto 55, 53100 Siena, Italy.

J Med Chem ; 42(9): 1556-75, 1999 May 06.

Article in En | MEDLINE | ID: mdl-10229626

Subject(s)

Piperazines/chemical synthesis; Receptors, Serotonin/drug effects; Serotonin Antagonists/chemical synthesis; Serotonin Receptor Agonists/chemical synthesis; Animals; Binding, Competitive; Brain/metabolism; Cell Line; Granisetron/metabolism; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Piperazines/chemistry; Piperazines/metabolism; Piperazines/pharmacology; Rats; Rats, Wistar; Receptors, Serotonin/metabolism; Receptors, Serotonin, 5-HT3; Serotonin Antagonists/chemistry; Serotonin Antagonists/metabolism; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/chemistry; Serotonin Receptor Agonists/metabolism; Serotonin Receptor Agonists/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Serotonin Antagonists / Receptors, Serotonin / Serotonin Receptor Agonists Type of study: Qualitative_research Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Document type: Article Affiliation country: Italy

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