Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization.

Munro, J; Stott, F J; Vousden, K H; Peters, G; Parkinson, E K

Munro, J; Stott, F J; Vousden, K H; Peters, G; Parkinson, E K.

Affiliation

Munro J; Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Glasgow, United Kingdom.

Cancer Res ; 59(11): 2516-21, 1999 Jun 01.

Article in En | MEDLINE | ID: mdl-10363964

Subject(s)

Cellular Senescence/physiology; Cyclin-Dependent Kinase Inhibitor p16/metabolism; Gene Deletion; Keratinocytes/physiology; Proteins/physiology; 3T3 Cells; Animals; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/metabolism; Cell Line, Transformed; Cellular Senescence/genetics; Cyclin-Dependent Kinase Inhibitor p16/genetics; Cyclin-Dependent Kinase Inhibitor p21; Cyclins/metabolism; Exons/genetics; Humans; Mice; Proteins/genetics; Tumor Cells, Cultured; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Keratinocytes / Cellular Senescence / Gene Deletion / Cyclin-Dependent Kinase Inhibitor p16 Limits: Animals / Humans Language: En Journal: Cancer Res Year: 1999 Document type: Article Affiliation country: United kingdom Country of publication: United States

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