Liposomes as carriers of the antiretroviral agent dideoxycytidine-5'-triphosphate.
Int J Pharm
; 180(2): 261-70, 1999 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-10370196
ABSTRACT
The presence and replication of the human immunodeficiency virus (HIV) in cells of the mononuclear phagocyte system (MPS) together with the preferential uptake of liposomes in macrophages suggest that liposomes can become a valuable carrier of anti-HIV agents. Moreover, liposomes reduce toxicity of encapsulated drugs and protect encapsulated drugs against rapid degradation in the blood circulation. To overcome problems associated with the administration of free nucleosides and to improve targeting to the MPS, dideoxycytidine-5'-triphosphate (ddCTP) was encapsulated in liposomes. Liposomes were stable with regard to retention of the entrapped drug, particle size and chemical stability of ddCTP. Results obtained with liposome encapsulated ddCTP in the murine acquired immunodeficiency syndrome (MAIDS) model indicate that ddCTP encapsulated in liposomes can reduce proviral DNA in cells of the mononuclear phagocyte system (MPS) in both spleen and bone marrow.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anti-HIV Agents
/
Deoxycytosine Nucleotides
Limits:
Animals
Language:
En
Journal:
Int J Pharm
Year:
1999
Document type:
Article
Affiliation country:
Netherlands