Potent antihyperalgesic activity without tolerance produced by glycine site antagonist of N-methyl-D-aspartate receptor GV196771A.

Quartaroli, M; Carignani, C; Dal Forno, G; Mugnaini, M; Ugolini, A; Arban, R; Bettelini, L; Maraia, G; Belardetti, F; Reggiani, A; Trist, D G; Ratti, E; Di Fabio, R; Corsi, M

Quartaroli, M; Carignani, C; Dal Forno, G; Mugnaini, M; Ugolini, A; Arban, R; Bettelini, L; Maraia, G; Belardetti, F; Reggiani, A; Trist, D G; Ratti, E; Di Fabio, R; Corsi, M.

Affiliation

Quartaroli M; GlaxoWellcome S.p.A., Medicines Research Centre, Department of Pharmacology, Verona, Italy. mq7886@glaxowellcome.co.uk

J Pharmacol Exp Ther ; 290(1): 158-69, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10381772

Subject(s)

Analgesics, Non-Narcotic/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Hyperalgesia/drug therapy; Indoles/pharmacology; Pyrroles/pharmacology; Receptors, Glycine/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Animals; Behavior, Animal/drug effects; Binding, Competitive; Cerebral Cortex/metabolism; Drug Tolerance; Electrophysiology; Embryo, Mammalian; In Vitro Techniques; Male; Mice; Pain Measurement/drug effects; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Spinal Cord/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Receptors, N-Methyl-D-Aspartate / Receptors, Glycine / Excitatory Amino Acid Antagonists / Analgesics, Non-Narcotic / Hyperalgesia / Indoles Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1999 Document type: Article Affiliation country: Italy

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