Guanidine hydrochloride exerts dual effects on the tryptophan synthase alpha 2 beta 2 complex as a cation activator and as a modulator of the active site conformation.

Fan, Y X; McPhie, P; Miles, E W

Fan, Y X; McPhie, P; Miles, E W.

Affiliation

Fan YX; Section on Enzyme Structure and Function, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

Biochemistry ; 38(24): 7881-90, 1999 Jun 15.

Article in En | MEDLINE | ID: mdl-10387029

Subject(s)

Guanidine/chemistry; Tryptophan Synthase/chemistry; Tryptophan Synthase/metabolism; Binding Sites; Cations, Monovalent/chemistry; Chromatography, Gel; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Guanidine/pharmacology; Macromolecular Substances; Models, Chemical; Protein Conformation/drug effects; Serine/chemistry; Spectrometry, Fluorescence; Spectrophotometry; Urea/chemistry; Urea/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan Synthase / Guanidine Type of study: Prognostic_studies Language: En Journal: Biochemistry Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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