[Morphine decreases the voltage sensitivity of the slow sodium channels]. / Morfine umen'shaet chuvstvitel'nost' k potentsialu medlennykh natrievykh kanalov.
Ross Fiziol Zh Im I M Sechenova
; 85(2): 225-36, 1999 Feb.
Article
in Ru
| MEDLINE
| ID: mdl-10389179
ABSTRACT
Morphine was shown to decrease in a dose-dependent manner the effective charge transfer in tetrodotoxin-resistant (TTXr) sodium channel activation system in short-term cultured dorsal root ganglion cells. Morphine seems to interact with opioid receptors because of total block of the binding by naloxone and naltrexone. Neither activating, nor inhibiting G-protein agents exerted any effect on this process. The morphine signal was blocked by extracellular application of 2 x 10(-4) M ouabain. The findings suggest existence of sodium signalling pathway involving receptors, Na+, K(+)-ATPase and the TTXr sodium channels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Channels
/
Morphine
/
Neurons
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
Ru
Journal:
Ross Fiziol Zh Im I M Sechenova
Journal subject:
FISIOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
RUSSIA