Motilin-producing liver and bone metastases evidenced 14 years after resection of a rectal polyp.
Am J Surg Pathol
; 23(7): 838-43, 1999 Jul.
Article
in En
| MEDLINE
| ID: mdl-10403308
ABSTRACT
A 62-year-old man with a history of a resected rectal polyp was diagnosed 14 years later with right liver and multiple bone metastases. The liver biopsy showed a malignant epithelial tumor that was positive for neuron-specific enolase immunostaining and negative for chromogranin. Electron microscopy was characteristic of that for an endocrine tumor. Most circulating hormonal peptide levels were within normal ranges and only motilin level was elevated. On the right hepatectomy, the three large metastases had a histologic picture suggestive of an endocrine tumor. Immunohistochemistry revealed in some areas numerous tumor cells expressing motilin, and a few cells were strongly positive for pancreatic polypeptide and somatostatin. The retrospective analysis of the rectal polyp showed a similar histology and immunohistochemical profile, indicating that this lesion was the primary tumor. Motilin-positive cells from one of the hepatic lesions were identified on semithin sections and further processed for electron microscopy. Neurosecretory granules were numerous in all cells. Immunoelectron localization enabled us to characterize the motilin-containing neurosecretory granules, which had a mean diameter of 168.3x38.1 nm. Although not all tumor cells were motilin-positive, a diagnosis of motilinoma for the rectal polyp and its hepatic and bone metastases was proposed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyps
/
Rectal Neoplasms
/
Bone Neoplasms
/
Motilin
/
Carcinoid Tumor
/
Liver Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Surg Pathol
Year:
1999
Document type:
Article
Affiliation country:
Belgium