Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.

Miller, W H; Bondinell, W E; Cousins, R D; Erhard, K F; Jakas, D R; Keenan, R M; Ku, T W; Newlander, K A; Ross, S T; Haltiwanger, R C; Bradbeer, J; Drake, F H; Gowen, M; Hoffman, S J; Hwang, S M; James, I E; Lark, M W; Lechowska, B; Rieman, D J; Stroup, G B; Vasko-Moser, J A; Zembryki, D L; Azzarano, L M; Adams, P C; Huffman, W F

Miller, W H; Bondinell, W E; Cousins, R D; Erhard, K F; Jakas, D R; Keenan, R M; Ku, T W; Newlander, K A; Ross, S T; Haltiwanger, R C; Bradbeer, J; Drake, F H; Gowen, M; Hoffman, S J; Hwang, S M; James, I E; Lark, M W; Lechowska, B; Rieman, D J; Stroup, G B; Vasko-Moser, J A; Zembryki, D L; Azzarano, L M; Adams, P C; Huffman, W F.

Affiliation

Miller WH; Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.

Bioorg Med Chem Lett ; 9(13): 1807-12, 1999 Jul 05.

Article in En | MEDLINE | ID: mdl-10406646

Subject(s)

Acetates/chemical synthesis; Acetates/pharmacokinetics; Aminopyridines/chemical synthesis; Aminopyridines/pharmacokinetics; Osteoporosis/drug therapy; Receptors, Vitronectin/antagonists & inhibitors; Administration, Oral; Animals; Benzodiazepinones/chemical synthesis; Benzodiazepinones/pharmacokinetics; Biological Availability; Disease Models, Animal; Kinetics; Rats; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Receptors, Vitronectin / Aminopyridines / Acetates Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 1999 Document type: Article Affiliation country: United States Country of publication: United kingdom

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