Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.

Whitlow, M; Arnaiz, D O; Buckman, B O; Davey, D D; Griedel, B; Guilford, W J; Koovakkat, S K; Liang, A; Mohan, R; Phillips, G B; Seto, M; Shaw, K J; Xu, W; Zhao, Z; Light, D R; Morrissey, M M

Whitlow, M; Arnaiz, D O; Buckman, B O; Davey, D D; Griedel, B; Guilford, W J; Koovakkat, S K; Liang, A; Mohan, R; Phillips, G B; Seto, M; Shaw, K J; Xu, W; Zhao, Z; Light, D R; Morrissey, M M.

Affiliation

Whitlow M; Berlex Biosciences, 15049 San Pablo Avenue, PO Box 4099, Richmond, California 94804, USA. marc_whitlow@berlex.com

Acta Crystallogr D Biol Crystallogr ; 55(Pt 8): 1395-404, 1999 Aug.

Article in En | MEDLINE | ID: mdl-10417407

Subject(s)

Factor Xa Inhibitors; Trypsin/chemistry; Animals; Cattle; Crystallography, X-Ray; Drug Design; Electrochemistry; Humans; In Vitro Techniques; Macromolecular Substances; Models, Molecular; Molecular Conformation; Protein Binding; Protein Conformation

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Collection: 01-internacional Database: MEDLINE Main subject: Trypsin / Factor Xa Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Crystallogr D Biol Crystallogr Year: 1999 Document type: Article Affiliation country: United States

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