Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction.

Murata, M; Tsujikawa, M; Kawanishi, S

Murata, M; Tsujikawa, M; Kawanishi, S.

Affiliation

Murata M; Department of Hygiene, Mie University School of Medicine, Tsu, Mie, 514-8507, Japan.

Biochem Biophys Res Commun ; 261(2): 478-83, 1999 Aug 02.

Article in En | MEDLINE | ID: mdl-10425210

Subject(s)

Carcinogens/toxicity; DNA Damage; Reproduction/drug effects; Toluene/metabolism; Toluene/toxicity; 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzoquinones/metabolism; Benzoquinones/toxicity; Binding Sites; DNA/chemistry; DNA/drug effects; Deoxyguanosine/analogs & derivatives; Deoxyguanosine/biosynthesis; Free Radical Scavengers/pharmacology; Humans; Hydroquinones/metabolism; Hydroquinones/toxicity; Male; Oxidation-Reduction; Superoxides/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Reproduction / Toluene / DNA Damage / Carcinogens Limits: Animals / Humans / Male Language: En Journal: Biochem Biophys Res Commun Year: 1999 Document type: Article Affiliation country: Japan Country of publication: United States

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