Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH.
Braz J Med Biol Res
; 32(7): 841-3, 1999 Jul.
Article
in En
| MEDLINE
| ID: mdl-10454742
ABSTRACT
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proto-Oncogene Proteins c-fos
/
Adrenal Cortex Neoplasms
/
Adrenocorticotropic Hormone
/
Mitogen-Activated Protein Kinase 1
/
Fibroblast Growth Factors
Limits:
Animals
Language:
En
Journal:
Braz J Med Biol Res
Year:
1999
Document type:
Article
Affiliation country:
Brazil