Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.

Belaud-Rotureau, M A; Lacombe, F; Durrieu, F; Vial, J P; Lacoste, L; Bernard, P; Belloc, F

Belaud-Rotureau, M A; Lacombe, F; Durrieu, F; Vial, J P; Lacoste, L; Bernard, P; Belloc, F.

Affiliation

Belaud-Rotureau MA; Laboratoire d'Hématologie, Hôpital Haut-Levêque, 33604 Pessac, France.

Cell Death Differ ; 6(8): 788-95, 1999 Aug.

Article in En | MEDLINE | ID: mdl-10467353

Subject(s)

Apoptosis; Caspases/metabolism; Cysteine Proteinase Inhibitors/metabolism; Enzyme Inhibitors/metabolism; Leupeptins/metabolism; Sphingosine/analogs & derivatives; Caspase 3; Caspase Inhibitors; Cysteine Proteinase Inhibitors/pharmacology; Enzyme Activation; Enzyme Inhibitors/pharmacology; Female; Humans; Leupeptins/pharmacology; Necrosis; Sphingosine/metabolism; Sphingosine/pharmacology; Tumor Cells, Cultured; U937 Cells; fas Receptor/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Cysteine Proteinase Inhibitors / Apoptosis / Caspases / Enzyme Inhibitors / Leupeptins Limits: Female / Humans Language: En Journal: Cell Death Differ Year: 1999 Document type: Article Affiliation country: France Country of publication: United kingdom

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