Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.

Frenette, R; Hutchinson, J H; Léger, S; Thérien, M; Brideau, C; Chan, C C; Charleson, S; Ethier, D; Guay, J; Jones, T R; McAuliffe, M; Piechuta, H; Riendeau, D; Tagari, P; Girard, Y

Frenette, R; Hutchinson, J H; Léger, S; Thérien, M; Brideau, C; Chan, C C; Charleson, S; Ethier, D; Guay, J; Jones, T R; McAuliffe, M; Piechuta, H; Riendeau, D; Tagari, P; Girard, Y.

Affiliation

Frenette R; Merck Frosst Center for Therapeutic Research, Pointe-Claire - Dorval, Québec, Canada.

Bioorg Med Chem Lett ; 9(16): 2391-6, 1999 Aug 16.

Article in En | MEDLINE | ID: mdl-10476875

Subject(s)

Carrier Proteins/antagonists & inhibitors; Indoles/chemistry; Indoles/pharmacology; Lipoxygenase Inhibitors/chemistry; Membrane Proteins/antagonists & inhibitors; Quinolines/chemistry; 5-Lipoxygenase-Activating Proteins; Animals; Dogs; Humans; In Vitro Techniques; Indoles/therapeutic use; Lipoxygenase Inhibitors/pharmacology; Lipoxygenase Inhibitors/therapeutic use; Quinolines/pharmacology; Quinolines/therapeutic use; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Carrier Proteins / Lipoxygenase Inhibitors / Indoles / Membrane Proteins Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 1999 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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