CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.

Whitmire, J K; Flavell, R A; Grewal, I S; Larsen, C P; Pearson, T C; Ahmed, R

Whitmire, J K; Flavell, R A; Grewal, I S; Larsen, C P; Pearson, T C; Ahmed, R.

Affiliation

Whitmire JK; Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

J Immunol ; 163(6): 3194-201, 1999 Sep 15.

Article in En | MEDLINE | ID: mdl-10477587

Subject(s)

CD4-Positive T-Lymphocytes/immunology; CD40 Antigens/physiology; CD8-Positive T-Lymphocytes/immunology; Lymphocytic Choriomeningitis/prevention & control; Lymphocytic choriomeningitis virus/immunology; Membrane Glycoproteins/physiology; Animals; CD4-Positive T-Lymphocytes/virology; CD40 Antigens/metabolism; CD40 Ligand; CD8-Positive T-Lymphocytes/virology; Chronic Disease; Clone Cells; Drug Synergism; Epitopes, T-Lymphocyte/analysis; Ligands; Lymphocyte Activation/genetics; Lymphocytic Choriomeningitis/immunology; Lymphocytic Choriomeningitis/virology; Membrane Glycoproteins/deficiency; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / CD40 Antigens / Lymphocytic Choriomeningitis / Lymphocytic choriomeningitis virus Limits: Animals Language: En Journal: J Immunol Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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