A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

Metz, S A; Meredith, M; Vadakekalam, J; Rabaglia, M E; Kowluru, A

Metz, S A; Meredith, M; Vadakekalam, J; Rabaglia, M E; Kowluru, A.

Affiliation

Metz SA; Pacific Northwest Research Institute, Seattle, Washington 98122, USA. smetz@pnri.org

Diabetes ; 48(9): 1754-62, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10480605

Subject(s)

Diabetes Mellitus, Experimental/physiopathology; Diabetes Mellitus, Type 2/physiopathology; Insulin/metabolism; Islets of Langerhans/metabolism; Animals; Disease Models, Animal; Humans; Insulin Secretion; Purine Nucleotides/metabolism; Rats; Rats, Inbred Strains; Rats, Wistar; Secretory Rate; Signal Transduction/physiology; Type C Phospholipases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Insulin Limits: Animals / Humans Language: En Journal: Diabetes Year: 1999 Document type: Article Affiliation country: United States

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