Alzheimer's disease pathology in motor cortex in dementia with Lewy bodies clinically mimicking corticobasal degeneration.
Acta Neuropathol
; 98(3): 317-22, 1999 Sep.
Article
in En
| MEDLINE
| ID: mdl-10483792
We report here a 70-year-old woman whose initial clinical presentation suggested corticobasal degeneration, but autopsy revealed dementia with Lewy bodies (DLB) with severe Alzheimer's disease (AD)-type pathology accentuated in the motor cortex, in conjunction with a high burden of both cortical and brain stem LB. Review of the literature disclosed four patients with AD whose peri-Rolandic region was particularly involved by the disease and who exhibited similar clinical and neuropathological findings as in our patient except they lacked LB. It appears that DLB if associated with severe AD-type pathology can, like some unusual cases of AD, mimic corticobasal degeneration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lewy Bodies
/
Neurodegenerative Diseases
/
Alzheimer Disease
/
Motor Cortex
Type of study:
Diagnostic_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Acta Neuropathol
Year:
1999
Document type:
Article
Affiliation country:
United States
Country of publication:
Germany