MR imaging of pancreatic lesions. Comparison of manganese-DPDP and gadolinium chelate.
Invest Radiol
; 34(9): 589-95, 1999 Sep.
Article
in En
| MEDLINE
| ID: mdl-10485075
ABSTRACT
RATIONALE AND OBJECTIVES:
To compare manganese-DPDP-enhanced and gadolinium-DTPA-enhanced MR imaging in patients suspected of having pancreatic cancer.METHODS:
Fifteen patients who underwent MR imaging for suspected pancreatic cancer and received gadolinium-DTPA took part in a clinical phase III trial in which the efficacy of manganese-DPDP for detection of pancreatic cancer was evaluated. T1-weighted gradient-echo (GRE) images with and without fat suppression were used. Signal-to-noise ratio and contrast-to-noise ratio were calculated before and after the administration of each contrast agent. Image quality was assessed using a four-step score; delineation of the normal pancreas was assessed by two readers in consensus.RESULTS:
In terms of pancreatic signal-to-noise ratio, only gadolinium-DTPA-enhanced fat-suppressed and non-fat-suppressed GRE imaging showed a significant (P < 0.001) increase (72% and 61%, respectively). In the patients with a focal pancreatic lesion (n = 14), a significant increase in contrast-to-noise ratio was found only in manganese-DPDP-enhanced GRE imaging without (106%) and with (82%) fat saturation. Qualitative image analysis demonstrated a significant improvement of manganese-DPDP-enhanced fat-suppressed MR images in delineating the pancreatic parenchyma (P < 0.01) as well as pancreatic tumors (P < 0.01).CONCLUSIONS:
T1-weighted manganese-DPDP-enhanced GRE imaging with fat saturation should be regarded as the most suitable combination for detecting a pancreatic lesion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreas
/
Pancreatic Diseases
/
Pyridoxal Phosphate
/
Magnetic Resonance Imaging
/
Edetic Acid
/
Contrast Media
/
Gadolinium DTPA
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Qualitative_research
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Invest Radiol
Year:
1999
Document type:
Article
Affiliation country:
Germany