Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats.

Cho, H Y; Hotchkiss, J A; Harkema, J R

Cho, H Y; Hotchkiss, J A; Harkema, J R.

Affiliation

Cho HY; Department of Pharmacology and Toxicology, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.

Toxicol Sci ; 51(1): 135-45, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10496685

Subject(s)

Goblet Cells/drug effects; Metaplasia/chemically induced; Oxidants, Photochemical/toxicity; Ozone/toxicity; Rhinitis/chemically induced; Administration, Inhalation; Animals; Bromodeoxyuridine/metabolism; Cell Count; DNA/biosynthesis; Goblet Cells/metabolism; Goblet Cells/pathology; Male; Metaplasia/pathology; Mucin-5B; Mucins/genetics; Mucins/metabolism; Neutrophils/drug effects; Neutrophils/pathology; RNA, Messenger/metabolism; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Rhinitis/metabolism; Rhinitis/pathology; Turbinates/drug effects; Turbinates/metabolism; Turbinates/pathology; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidants, Photochemical / Ozone / Rhinitis / Goblet Cells / Metaplasia Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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