Electrical activity and gene expression in the development of vertebrate neural circuits.
J Neurobiol
; 41(1): 148-57, 1999 Oct.
Article
in En
| MEDLINE
| ID: mdl-10504202
ABSTRACT
Over the past several decades, anatomical and electrophysiological analyses have demonstrated that the electrical activity of neurons is required for development of the precise patterns of synaptic connectivity found in the adult central nervous system. However, knowledge of the molecular cascades that underlie activity-dependent synaptic development remains rudimentary. As a result, many fundamental issues remain unresolved. Recent advances in differential cloning have begun to provide the tools and insight necessary to bring a molecular level of understanding to principles of activity-dependent synaptic development established via classic systems approaches.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Visual Pathways
/
Brain Chemistry
/
Gene Expression Regulation, Developmental
/
Neuronal Plasticity
/
Neurons
Limits:
Animals
Language:
En
Journal:
J Neurobiol
Year:
1999
Document type:
Article
Affiliation country:
United States