Killing activities of trovafloxacin alone and in combination with beta-lactam agents, rifampin, or vancomycin against Streptococcus pneumoniae isolates with various susceptibilities to extended-spectrum cephalosporins at concentrations clinically achievable in cerebrospinal fluid.
Antimicrob Agents Chemother
; 43(10): 2372-5, 1999 Oct.
Article
in En
| MEDLINE
| ID: mdl-10508009
ABSTRACT
The killing activities of trovafloxacin alone and in combination with beta-lactam agents (extended-spectrum cephalosporins, meropenem), rifampin, or vancomycin were evaluated against 20 genotypically characterized Streptococcus pneumoniae isolates for which amoxicillin MICs were >/=4 microg/ml (cefotaxime MICs, >/=4 microg/ml for six strains) at concentrations clinically achievable in cerebrospinal fluid. At 6 h the mean killing activity of trovafloxacin alone (range, 2.6 to 2.9 log(10) CFU/ml) did not vary significantly according to the susceptibility of the strains to beta-lactam agents. The activities of trovafloxacin or vancomycin added to the beta-lactam agents and the combination trovafloxacin-vancomycin were additive or indifferent. Against the ceftriaxone-resistant isolates, the killing activity of the combination of a beta-lactam agent and trovafloxacin did not differ significantly from that of a beta-lactam agent and vancomycin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus pneumoniae
/
Cephalosporin Resistance
/
Fluoroquinolones
/
Anti-Infective Agents
/
Naphthyridines
Limits:
Humans
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
1999
Document type:
Article
Affiliation country:
France